The Fifth and Last Force of Illness: Oxidative Stress (or “Rusting”)

We are all rusting.  In this sense, we are all like apples – going brown with age (think “age Oxidative Stressspots”).   The process of oxidizing is a necessary component of burning fuel to make energy, but the by-products of this process are highly reactive oxygen molecules known as “free radicals” – which can damage the tissues unless there is enough “anti-oxidation” happening to counteract free radical production.   This state of imbalance is called Oxidative Stress, or the unchecked effects of oxygen on the body.

Research has shown that virtually all illnesses have an increased level of oxidative stress in common.

Heart disease, cancer, osteoarthritis, rheumatoid arthritis, diabetes and neurological problems like alzheimers’s, parkinson’s and multiple sclerosis are some common diseases that appear to be triggered by oxidative stress.  The related symptoms include fatigue, weakness, muscle and joint pain, headaches, itchiness, digestion problems, anxiety and depression – to mention only a few.

VitaminsThe source of oxidative stress can be both internal and external.  Internally, we may have nutritional deficiencies of the “antioxidants” – like Zinc, C, Selenium, and E.  How we live our lives also contributes to this imbalance as smoking, alcohol, excessive exercise, pharmacologic drugs and overeating contribute to oxidative stress.  Blood sugar imbalance leads to oxidative stress, and so does being overweight.  External sources include exposure to pollution, pesticides, petrochemicals and heavy metals.

Tests for Oxidative Stress include measuring lipid peroxides, superoxide dismutase, glutathione peroxidase, catalase and/or glutathione in the blood.  Certain free radical markers like catechol and 2,3 – dihydroxybenzoate can be measured in the urine.  Blood levels of the antioxidant nutrients A, D, E, CoEnzyme Q10 and beta-carotene can be measured in the blood as well.

We are all at risk for Oxidative Stress – since the majority of us do not get enough antioxidant-containing through our food.  I believe that supplementation of these nutrients is often a necessary first step – if the individual already has signs of oxidative stress.  This being said, there are no supplements that can take the place of optimizing your diet.  Choose to eat high nutrient-to-calorie ratio foods rather than eating meals or snacks which are high in calories but low in antioxidants.  Eliminate anything “white” or processed from your diet i.e. white sugar, white flour, white bread, white rice and white pasta.  Dramatically increase the colourful vegetables and fruits in your diet which contain antioxidants like lycopene, lutein and proanthocyandins.  “You are what you eat” is an appropriate phrase.  As Mr. Spock might say….”Eat Right, Live Long and Prosper”!

Until next time…..

Force of Illness #3: Inflammation & Disease

The “Third Force of Illness” is Inflammation.  The inflammatory process is a natural body reaction to injury, infections, allergens, toxins, pollution, pesticides, food additives, drugs, cosmetics, chemicals, free radicals and oxidative stress.  The five associated signs that the process of inflammation is occurring are redness, swelling, heat, pain and loss of function.  The first three signs are the ones most often associated with inflammation – and we have all experienced it.  It is usually local and self-limited.  The body runs into trouble, however, when inflammation is excessive, chronic or systemic.

As strange as it sounds, the most common externally-generated cause of inflammation isBlue cold gel pack to kill the pain what happens in the digestive tract.  Even though we consider the “gut” is inside, it is actually “outside” us.  If we turned ourselves inside-out, the gut would be on the outside (like the skin).  The gastrointestinal tract is one of our primary defenses against invaders.   In many ways, it is an extension of the skin and similarly protective.  When the gut is inflamed, the inflammation process occurs in other areas of the body – like the covering of the bones and the walls of the arteries.  Any arthritis or arteriosclerosis has at its roots this inflammatory process.  As an interesting side-note, researchers are finding  that certain micro-organisms exist in the wall of diseased arteries.  We may find that cardiovascular disease may be linked to the presence of one or more of these organisms triggering the inflammatory response – just like Helicobacter pylori has been linked to the development of stomach ulcers.

In other words, gut function – especially an “inflamed” gut – affects other systems directly.  The digestive tract is a major regulator of the immune system.  Even though the source of the inflammation may be different, the end result is the same i.e., inflammation activates the immune system systemically.  Whether it starts in your pinky finger or your molar, inflammation puts your immune system on alert.  Reducing inflammation in the gut can, and does, have a modulating effect on the majority of disease processes that have an immune system component.

By far, the most common internally-triggered factors for chronic inflammation are free High resolution 3D human for anatomy,medicine and healthradicals and oxidative stress – which can be caused by anything that depletes the body of “antioxidants” e.g., overeating, obesity, chronic infections, toxins, and so on.  Please understand that free radicals are one of the naturally-occurring by-products of cellular metabolism.  Free radicals are kept from damaging tissue by “antioxidants” which neutralize them.   The problem results from an imbalance between free radical production and free radical neutralization.  Unadulterated colourful vegetables and fruits are perhaps the best way to get your daily dose of antioxidants e.g., vitamins A,D,E, K, C.  There are also certain supplements, like N.A.C., that increase other important antioxidants like glutathione.

Virtually all of us are antioxidant deficient, with inflamed digestive tracts and low-grade chronic inflammation.   This not only puts a heavy burden on the body, but it is my contention that it takes its toll on the Brain/Mind as well.  Much of the anxiety and depression experienced by our young people (which I consider epidemic) is directly related to poor diet and digestion.  An inflamed gut, most definitely can lead to an inflamed mind – and drugs are not the solution.  Mind what you eat, and eat for your mind.  Say “no” to your latte and say “hello” to you morning antioxidant smoothie!

Until next time……

Dr. Gatis

Are You Suffering From Sludge?

In a previous blog, I mentioned the book “Ultraprevention” by Dr. Mark Hyman, M.D.   According to Dr. Hyman, there are Five Forces of Illness.  The First of these Forces is what he calls the “sludge” factor.  Sludge (from a process I like to call “sludging”) is a term that means the result of abnormal or incomplete digestion and absorption of food.  Many of us are deluded into thinking that eating “right” i.e., eating lean meats, fruits, vegetables and cereals while avoiding fatty foods,  means that we don’t have to consider the possibility that we are malnourished.  This is unfortunately untrue.   Diet is important, of course, but how your body processes food is as important as the food itself.

Digestion, the breakdown of food into its components is complicated and involves severalHuman internal organs key players – the most important being hydrochloric acid from the stomach, pancreatic enzymes and bile from the liver/gallbladder.  If all of these digestive factors are working well, then there should be no fats, carbohydrates or proteins in the fecal material.  If there is, then either the digestion or absorption process has gone wrong.  Many individuals, for example, say that they eat well – but have digestive problems like chronic diarrhea, constipation or abdominal pain that is unrelated to an overt pathology.

It is now known that there is a process, called endothelial dysfunction, which occurs in the lining of the stomach and digestive tract, the lining of the arteries, the lining of the bones, the skin and the blood-brain barrier .  The same factors that cause inflammation in the gut can also cause inflammation in these other areas.   When a patient presents with symptoms on the skin (like psoriasis or eczema), autoimmune reactions or demonstrated arterial disease, the first thing that an ND suspects is a problem with digestion or absorption leading to a state of malnutrition.  Malnutrition in this sense is the chronic lack of certain essential nutrients that are either not being supplied in the diet or less-then-optimally absorbed that are necessary for the optimum functioning of the system in question.

70% of our immune system is located in the gut because swallowing “germs” is one of their major entrance routes into the body.   Any protein that is not recognized as yours is considered a potential invader and attacked.  The last thing that you want is your body to react against a food component.

Incomplete digestion is the major contributor for the digestion of food sensitivities.  Food How Do You Feel Question 3d Wordssensitivities occur when a food (especially protein) is not digested fully.   These incomplete breakdown particles can enter the circulation and create an antibody response because they are seen by the body as a foreign protein.

One of the reasons food sensitivities develop is a lack of hydrochloric acid (or HCL) production by the stomach or enzymes by the pancreas.    HCL is necessary for the breakdown of proteins into single amino acids.  Single amino acids don’t trigger an immune response where tripeptides (three amino acids bound together) can.   HCL is also necessary for mineral absorption.  This is why individuals that are taking a drug like Tecta for overacid conditions on a daily basis will eventually suffer from osteopenia or soft bones – due to the reduction in mineral absorption.   It has also been related, I believe, to creating low thyroid conditions – probably for the same reason.

In summary, chronic health conditions are usually related to problems with “sludging” or abnormal digestion and absorption of foods.  This “sludge” interferes with the cell’s ability to optimally function and is one of the first signs of the beginning of illness.

In the next blog, we will talk about Force 2:  Impaired Metabolism or Burnout.

Until then……

Dr. Gatis